In the Know with Amol Sarva

In the Know with Amol Sarva · Feb 7, 2026

PJ Parson, Northzone and Spotify

🎙️ Episode Guide — PJ Parson (Northzone) Welcome to my series on OG NY Tech Celebrating 30 years of the New York tech ecosystem, from 1995 to now. PJ Parson is a partner at …

In the Know with Amol Sarva · Jan 30, 2026

Kevin Ryan, Alleycorp + MongoDB ++ Doubleclick, Dilbert

>updated with vibier sound!< Welcome to my series on OG NY Tech Celebrating 30 years of the New York tech ecosystem, from 1995 to now. Kevin Ryan joined DoubleClick in 1996, just months after …

In the Know with Amol Sarva · Dec 28, 2025

Howard Morgan, First Round and BCap

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Howard Morgan started as an engineer and professor in the early computing days, and …

In the Know with Amol Sarva · Dec 28, 2025

*Fred Wilson, Union Square Ventures

>updated with vibier sound!< Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Fred Wilson's USV is kind of a 'nuff said, to …

In the Know with Amol Sarva · Dec 28, 2025

Alan Patricof, APAX, Greycroft and Primetime

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Alan Patricof's been at it since he graduated from Columbia Business School just a …

In the Know with Amol Sarva · Nov 12, 2025

Ben Lerer, Thrillist and Lerer Hippeau

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Ben Lerer tells us what ideas led to the creation of a whole new …

In the Know with Amol Sarva · Oct 28, 2025

Dennis Crowley, Foursquare and Dodgeball

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Dennis Crowley tells us how he got to New York and the early internet …

In the Know with Amol Sarva · Oct 28, 2025

Albert Wenger, Union Square Ventures

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Albert Wenger tells me about his 20 years at USV, and how NY went …

In the Know with Amol Sarva · Oct 7, 2025

Owen Davis, Contour and NYC Seed

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Owen Davis tells us how advertising powered early NYC tech and the big transition …

In the Know with Amol Sarva · Oct 7, 2025

John Borthwick, Betaworks

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. John Borthwick tells us the roots story of media and art and agencies at …

In the Know with Amol Sarva · Jul 5, 2025

Pablos Holman from Deep Future VC on “invention” vs. just innovation

Pablos built one of the first decentralized money networks, the first experimental Blue Origin rockets, one of the first handheld computers, invented 1000s of new patents with Nathan Myhrvold, and most recently launched a …

In the Know with Amol Sarva · May 1, 2025

AI x Bio x NY: highlights from our conference

So you missed the all-day all-science+technology collection of superstars gathered by LifeX and Bits in Bio at Fenwick in New York? Wondering what the frontiers of foundation models in bio, longevity, startups and more …

In the Know with Amol Sarva · Apr 22, 2025

What’s super-investor Jim Mellon thinking about?

Jim, founder of Juvenescence, old China and Russia hand, and investor in our fund LifeX sends me an email every morning with lots of attachments that he read that morning. Here's what he's been …

In the Know with Amol Sarva · Apr 13, 2025

De-growth, de-acceleration from the Slow Down manifesto by Shohei Saito, by Amolbot

Read the post here: https://amol.sarva.co/%f0%9f%90%8c-kohei-saitos-slow-down-de-acc-manifesto/

In the Know with Amol Sarva · Apr 3, 2025

Cyborgs! Our AI and Bio Future, by Amolbot

I gave a talk in Stockholm last year, that I asked these robots to discuss. Hope you enjoy it. This doesn't look LIKE me but it does sort of resemble what I could possibly …

In the Know with Amol Sarva · Jan 26, 2025

What’s Om Malik interested in these days?

The legendary tech beat reporter is back with a team effort newsletter covering some of the most interesting people in tech. Listen in to hear what he's been thinking about over the last 10 …

In the Know with Amol Sarva · Jan 6, 2025

10 x Trends for AI x Health + Bio in 2025 from LifeX dealflow analysis, courtesy of Amolbot

We analyzed the 1,000s of companies we're watching and investing in at LifeX. We looked at every update email from every CEO and every conversation notes from every team member. And we made hits …

In the Know with Amol Sarva · Jan 6, 2025

20 Trends for 2025 in Health and Biopharma from Wall Street, synthesized by Amolbot

We synthesized the dozens of outlook reports from Wall Street analysts on health, biopharma, and related trends. Listen in to Amolbot (an automated Amol) and co-hosts.

In the Know with Amol Sarva · Jan 6, 2025

Techbio 2025 predictions from Amol’s inbox full of reports, via Amolbot

We synthesized the dozens of outlook reports from Silicon Valley observers of techbio for AI x Health startups and trends. Listen in to Amolbot (an automated Amol) and co-hosts.

In the Know with Amol Sarva · Aug 18, 2024

Soluble and insoluble fiber, food and gut health and their role in overall health with Dr. Will Bulsiewicz from Zoe

Dr. B is an expert on gut health and shouting its power from the rooftops, both in his practice and writings but also through the company Zoe where he is US medical director. Some …

In the Know with Amol Sarva · Aug 16, 2024

How food becomes energy and the view from sports nutrition on metabolism with Professor Derek Huffman of Einstein

The journey from food through digestion to your liver to energy stores and metabolizing work is the obsession of sports science - and hugely relevant to metabolic health overall. Let's get this perspective from …

In the Know with Amol Sarva · Aug 16, 2024

Food as medicine with physician and founder Jeff Alfonsi

The different foods we eat and how they interact make a huge difference in disease progression, weight, and everything else. Dr. Jeff Alfonsi is a practicing physician for years, and chief medical officer of …

In the Know with Amol Sarva · Aug 1, 2024

Pro biotics, pre biotics, and what your digestive system knows with Maya Kaelberer, Ph.D.

Let's understand an overlooked dimension of the weight loss revolution underway -- the microbes in the digestive system themselves, potentially where GLP-1s come from in the first place. Duke's gut biome expert Maya Kaelberer …

In the Know with Amol Sarva · Jul 31, 2024

Metformin, Rapamycin, the cellular mechanisms at the cutting edge of weight loss and longevity with Matt Kaeberlein, Ph.D.

Metabolic Health is the biggest medical breakthrough of the moment Let's understand the cellular mechanisms and some of the most promising and widely used drugs in the world with one of the foremost researchers …

In the Know with Amol Sarva · Jul 30, 2024

Bariatric surgery, the gut biome, and the interactions that create weight loss with surgery and nutrition professor Randy Seeley, Ph.D. at Michigan

Metabolic Health is the biggest medical breakthrough of the moment Mapping all the ways the GLP-1 drugs like Ozempic do and might work means we need to understand the biome and the efficacy of …

In the Know with Amol Sarva · Jul 29, 2024

Understanding blood sugar and insulin with world leader on diabetes Dr. John Buse of UNC

Metabolic Health is the biggest medical breakthrough of the moment Dr. John Buse has been at the forefront of diabetes research and endocrinology since before the first GLP-1 results started to become known. He …

In the Know with Amol Sarva · Jul 26, 2024

How weight loss works with Yale’s Dr. Waj Mehal

Metabolic Health is the biggest medical breakthrough of the moment We have one of the world's experts on the liver - the place your body stores lots of energy from food, and distributes it …

In the Know with Amol Sarva · Jul 25, 2024

How Ozempic works and what else could revolutionize metabolic health with James Peyer, Ph.D. of Cambrian Bio

Metabolic Health is the biggest medical breakthrough of the moment Get up to speed on the cellular biology with a fantastic overview from PhD scientist and founder of breakthrough pharma platform Cambrian Bio

In the Know with Amol Sarva · Aug 8, 2023

Alex Zhavoronokov from In Silico, the AI longevity drug discovery giant, on the revolution now and tomorrow

In the Know with Amol Sarva · Jul 10, 2023

Kristen Fortney from a16z-backed BioAge Labs on how they’re reversing the molecular mechanisms of aging