Audio versions of bioRxiv and medRxiv paper abstracts
A genome-wide CRISPR interference screen using an engineered trafficking biosensor reveals a role for RME-8 in opioid receptor regulation
Oct. 11, 2022
FBXL4 deficiency promotes mitophagy by elevating NIX.
Uterine histotroph and conceptus development. III. Adrenomedullin stimulates proliferation, migration and adhesion of porcine trophectoderm cells via AKT-TSC2-MTOR cell signaling pathway.
Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedge
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors
Oct. 12, 2022
Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA
Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation
The kleisin subunit controls the function of meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1
Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19
Endosomal Trafficking of Two Pore K+ Efflux Channel TWIK2 to Plasmalemma Mediates NLRP3 Inflammasome Activation and Inflammatory Injury
ERK3/MAPK6 dictates Cdc42/Rac1 activity and ARP2/3-dependent actin polymerization
Oct. 13, 2022
Muscle stem cell function is impaired in absence of Talpid3 - a gene required for primary cilia formation
Oct. 14, 2022
Metabolite profiling and cytotoxic activity of Andean potatoes: polyamines and glycoalkaloids as potential anticancer agents in human neuroblastoma cells in vitro
Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells
Differential chondrogenic differentiation between iPSC-derived from healthy and OA cartilage is associated with changes in epigenetic and metabolic transcriptomic signatures
In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization
Selective perijunctional MLCK1 recruitment in Crohn's disease: Identification of essential structural domains
IRE-1α is a key switch of pyroptosis and necroptosis in mice by dominating Gasdermin D
Metabolic rewiring of mitochondria in senescence revealed by time-resolved analysis of the mitochondrial proteome
The tendon interfascicular basement membrane provides a vascular niche for CD146+ pericyte cell subpopulations
Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket
Identifying human islet microRNAs associated with donor sex, age and body mass index
A Leaky Human Colon Model Reveals Uncoupled Apical/Basal Cytotoxicity in Early Clostridioides difficile Toxin Exposure
Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration
Peritubular macrophages phagocyte remains of undifferentiated spermatogonia in mouse testis
JADE1 and HBO1/KAT7 proteins in the cytokinesis of epithelial cells. The role of PHD zinc fingers.
The CRL4B E3 ligase regulates mitosis by recruiting phospho-specific DCAFs
Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota
Oct. 16, 2022
THE ALLOSTERICALLY MODULATED FREE FATTY ACID RECEPTOR 2 IS TRANSACTIVATED BY AN INCREASE IN THE CYTOSOLIC CONCENTRATION OF CALCIUM IONS
Opto-RhoGEFs: an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength
Oct. 17, 2022
The ER tether VAPA is required for proper cell motility and for anchoring ER-plasma membrane contact sites to focal adhesions
Centrosome amplification fine-tunes tubulin acetylation to differentially control intracellular organization
Decoding of YAP levels and dynamics by pluripotency factors
The Golgi complex is a regulatory hub for homologous recombination-mediated DNA repair.
Morphofunctional evaluation of the adrenal gland in rats submitted to nutritional restriction during pregnancy
Ploidy modulates cell size and metabolic rate in Xenopus embryos
Rates of global cellular translation and transcription during cell growth and the cell cycle in fission yeast.
Altered cohesin dynamics and histone H3K9 modifications contribute to mitotic defects in the cbf11Δ lipid metabolism mutant
Proteomic profiling reveals lysosomal heterogeneity in association with longevity
Class IIa HDACs reprogram mitochondrial metabolism to inhibit apoptosis and ferroptosis in response to lipotoxicity
Cell size contributes to single-cell proteome variation
Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy
RNA structural dynamics modulate EGFR-TKIs resistance through controlling YRDC translation in NSCLC cells
Oct. 18, 2022
Distinct contact guidance mechanisms in single endothelial cells and in monolayers
Oct. 19, 2022
Centriolar subdistal appendages promote double strand break repair through homologous recombination
RyR2 regulates store-operated Ca2+ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1
MagPEG: a complete extracellular vesicle isolation/analysis solution
Prevention of thrombocytopenia and thrombosis in heparin-induced thrombocytopenia (HIT) using deglycosylated KKO: A novel therapeutic?
PSC niche develops into immune-responsive blood cells capable of transdifferentiating into lamellocytes in Drosophila
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