What I like about the Mustache Rangers podcast is letting new episodes slowly gather in my listening queue until I have three or four, then I listen to them all at once. The rangers record in this manner, several episodes at a time, which they release over the course of a month. I can never listen to just one at a time--I need to listen to several because I always want more.
If you like improv, particularly improv based heavily in language, you'll like this podcast. The space and mustache theme doesn't hurt either, and if you can ever make their live show in Minneapolis, I recommend it.
Fans of improv will be aware of the drawbacks of the genre, best exemplified in the episode from 4/11/11. It's a rough combination of brilliant, terrible and weird. You've been warned, and you'll be warned again should you start listening to the audio. Godspeed if you do, and don't forget your bottle of Doc Johnson's Old Tyme Elixer. You'll need it.