This is a great podcast for people interested in computer hardware and other tech subjects. The easiest comparison is probably TWiT, but I feel that the TR podcast is superior in a number of ways.
First, the TR podcast is much more focused. You won't hear political opinions or what wine to buy. They do stray from computer hardware and occasionally talk about consumer electronics and PC gaming.
Second, the people on the show really know what they're talking about. It's incredibly rare for me to hear something on the TR podcast and think "that's wrong."
Finally, the show is well produced. The whole show is segmented into chapters, which makes it easy to skip to something that you care most about. It's clear that they have an idea of what they're going to talk about before they start, but they do so without making the show sound scripted or rehearsed.
Overall, it's a great show that has replaced TWiT as my first listen of the week. I just wish it was still weekly.