I've been listening to OtakuGeneration for a while now and have become a big fan. Its freeform discussions of anime, video games, gadgets, cartoon shows, movies, and more are thoroughly engrossing. The main personalities of the show provide a good balance of news, reviews, previews, and jokes. Add to that the occasional industry guest and you have yourself a recipe for success. An especially entertaining aspect of the show is how accessable the cast is. If you write in an email (or phone call) they will read your feedback, and give it a couple of minutes of discussion just about every time. Not only that, you can watch the show live as it is recorded on their video feed and talk to them in a live chatroom, providing realtime feedback just like a normal radio show. One additional thing worth noting is the excellent production quality of the show. While in the end it is the personalities and content that makes a show, the extra polish and effort that goes into recording and editing OtakuGeneration just makes it a joy to listen to.
If you're at all interested in anime, video games, or just about anything nerdy, don't let this gem of a show pass you by!