"The Restaurant Guys" succeeds where several other food podcasts fail for a number of reasons: 1) the volume level is generally consistent and easily understood; 2) they get interesting guests; 3) they do their homework so the guests are asked relevant questions; and 4) the conversation with the guests is flowing never sounds scripted.
You have to get used to the fact that this is a radio show and they will cut a guest off midsentence when a commercial break or the news comes on (most of these are cut out on the podcast, but you still hear one commercial for their restaurant). However, they will return to that point when they come back.
My favorites so far (I have only listened to around 30 or so episodes) are Thomas Keller, Anthony Bourdain, Secret Life of Lobsters (Corson), Heritage Farms, and Nina Planck. I listened to the interview with Doug Psaltis three times and think the guy got sandbagged. It was the only interview where I have seen these two offend someone and have them clam up. Usually they are so congenial, even when confrontational, which results in a very densely packed interview. Makes the 45-60 minute commute much more fun.