If you're looking for a tabletop RPG podcast with a bit of everything, this is it.
First off, I find something in pretty much every episode to shamelessly steal my games, whether it's a GM technique, a cool monster or plot device, or some website or GM tool.
The general discussion episodes are great if you're looking for advice about how to run a game, or how to be a better player. If you're new, this is a must listen. If you've been doing this a while, you'll still find cool nuggets to try at your table. Also, you'll feel really smart when you agree with them. They discuss pretty much everything from mechanics, story elements, managing a table, dealing with real life intruding on your gaming, etc.
The actual plays are great as well. The episodes are edited down well so you're not listening to somebody go looking for Cheetos and taking five minutes to look up the grapple rules. You'll also get to hear different GMs for the different campaigns, so you get to hear different GM styles and techniques in use.
Also, you'll get to hear different game systems used. Not sure if you'd want to try 13th Age or Fate Accelerated Edition? Check out their trial episodes of the systems and see how they actually work at the table. Several of the trial episodes, especially for the kick-started games, are run by the people who wrote them or are otherwise experts in the system, so you can get a good feel for what the game is supposed to play like.
There's also a smattering of RPG-related movie review episodes. If you watched the Dungeons and Dragons movie(s) and want to commiserate about the hours of your life you'll never get back, give them a listen.
One caveat: If you're a total audiophile and a completionist, the audio quality in the early episodes leaves a bit to be desired. But, it gets better.
Bottom line, these guys are passionate about the hobby, bringing new players into it, and helping you to have a great time at your own table, physical or virtual.
My players and I are having more fun at my table because of these guys, and that's what counts.