If horror is your game, then this is the podcast for you.
I've expanded my horror knowledge of past and present because of this podcast and have learned of new authors, young and old.
Dave Thomas is the perfect co-host (the prog in Brian's rock, if you will): he rants, offers insight and knowledgeable opinions about various topics from film to travel to food, and is a genuinely insanely funny man.
You get a real sense from listening to the podcast that Brian and Dave take this podcast seriously (especially when reporting on speculation and accusations, exposing the true creeps of the industry), but not too serious to bore you (there is the occasional F-Bomb).
Their guest interviews range from musicians to authors to film makers to publishers and they are always interesting, insightful.
Again, if you're into horror, The Horror Show with Brian Keene is in your tribe.