February 22, 2026

Clozapine: The Gold Standard for Treatment-Resistant Schizophrenia

In this episode, we break down clozapine — the gold standard treatment for treatment-resistant schizophrenia.Clozapine is one of the most effective antipsychotics available, but it requires careful monitoring and patient education due to its unique side-effect profile.We cover:• What defines treatment-resistant schizophrenia• Why clozapine is used• Mechanism of action (high-yield overview)• Smoking interactions and compliance issues• Slow titration and 48-hour restart rule• Agranulocytosis and blood monitoring schedule• Myocarditis risk• Seizure risk• Severe constipation (often underestimated)• Metabolic side effects• Clozapine and suicide risk reduction• How to counsel a patient in an OSCEWe also discuss key red flags — including infection symptoms that require urgent assessment.This episode is ideal for:Medical studentsOSCE preparationPsychiatry placementsFoundation doctorsGP and acute care rotationsClozapine is powerful — but only safe when monitored properly.

Also available on Apple Podcasts ↗